Takahiro Tsukimura Selected Research

globotriaosyl lysosphingolipid

9/2021	Does administration of hydroxychloroquine/amiodarone accelerate accumulation of globotriaosylceramide and globotriaosylsphingosine in Fabry mice?
7/2015	Clinical and biochemical investigation of male patients exhibiting membranous cytoplasmic bodies in biopsied kidney tissues; a pitfall in diagnosis of Fabry disease.
1/2015	Nano-LC-MS/MS for Quantification of Lyso-Gb3 and Its Analogues Reveals a Useful Biomarker for Fabry Disease.
1/2014	Plasma mutant α-galactosidase A protein and globotriaosylsphingosine level in Fabry disease.
11/2012	Mutant α-galactosidase A with M296I does not cause elevation of the plasma globotriaosylsphingosine level.
9/2010	Tissue and plasma globotriaosylsphingosine could be a biomarker for assessing enzyme replacement therapy for Fabry disease.
7/2010	Plasma globotriaosylsphingosine as a biomarker of Fabry disease.

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Takahiro Tsukimura Research Topics

Disease

26	Fabry Disease (Fabry's Disease) 12/2021 - 04/2009
5	Inborn Genetic Diseases (Disease, Hereditary) 01/2014 - 07/2010
2	Lysosomal Storage Diseases (Lysosomal Storage Disease) 09/2021 - 12/2020
2	Sandhoff Disease (Sandhoff's Disease) 01/2017 - 01/2011
2	Mucopolysaccharidosis I (Hurler Syndrome) 09/2013 - 09/2008
2	Glycogen Storage Disease Type II (Pompe's Disease) 06/2011 - 01/2007
1	Chronic Renal Insufficiency 12/2021
1	Azoospermia 01/2020
1	Proteinuria 12/2019
1	Nephrotic Syndrome (Syndrome, Nephrotic) 12/2019
1	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 12/2019
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2017
1	Gliosis 01/2017
1	Wilms Tumor (Wilm's Tumor) 05/2015
1	Chronic Kidney Failure (Chronic Renal Failure) 09/2012
1	Heart Diseases (Heart Disease) 04/2012
1	Tay-Sachs Disease 01/2011
1	Hypersensitivity (Allergy) 11/2009

Drug/Important Bio-Agent (IBA)

14	GalactosidasesIBA 12/2021 - 05/2011
9	globotriaosylceramide (globotriosylceramide)IBA 12/2021 - 11/2009
9	EnzymesIBA 01/2021 - 04/2009
7	globotriaosyl lysosphingolipidIBA 09/2021 - 07/2010
6	Biomarkers (Surrogate Marker)IBA 08/2018 - 07/2010
5	alpha-Galactosidase (Beano)IBA 01/2021 - 04/2009
4	GlycosphingolipidsIBA 01/2017 - 02/2012
3	GlycolipidsIBA 12/2021 - 09/2010
3	Proteins (Proteins, Gene)FDA Link 01/2014 - 11/2009
3	Imino SugarsIBA 06/2011 - 04/2009
2	agalsidase alfaIBA 12/2020 - 02/2012
2	agalsidase beta FDA Link 12/2020 - 01/2015
2	Protein Isoforms (Isoforms)IBA 01/2017 - 01/2015
2	AntibodiesIBA 05/2015 - 01/2015
2	Iduronidase (alpha-L-Iduronidase)IBA 09/2013 - 09/2008
2	Polysaccharides (Glycans)IBA 09/2013 - 02/2012
2	NucleotidesIBA 09/2012 - 04/2012
1	Phospholipids (Phosphatides)FDA LinkGeneric 09/2021
1	Pharmaceutical PreparationsIBA 09/2021
1	CationsIBA 12/2020
1	Mannose (D-Mannose)IBA 12/2020
1	CollagenIBA 01/2020
1	Peptides (Polypeptides)IBA 01/2020
1	Protamines (Protamine Sulfate)FDA Link 01/2020
1	SteroidsIBA 12/2019
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/2019
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2017
1	G(M2) Ganglioside (Ganglioside GM2)IBA 01/2017
1	Hexosaminidases (Hexosaminidase)IBA 01/2017
1	AutoantibodiesIBA 01/2017
1	Fingolimod Hydrochloride (FTY720)FDA Link 01/2017
1	podocalyxinIBA 05/2015
1	VimentinIBA 05/2015
1	migalastatIBA 07/2014
1	Heparitin Sulfate (Heparan Sulfate)IBA 09/2013
1	Glycoproteins (Glycoprotein)IBA 02/2012
1	Hexosaminidase A (Hex A)IBA 01/2011
1	GangliosidesIBA 01/2011
1	lysoganglioside G(M2)IBA 01/2011
1	alpha-N-Acetylgalactosaminidase (N-Acetyl-alpha-D-Galactosaminidase)IBA 11/2009
1	Mutant Proteins (Protein, Mutant)IBA 01/2007
1	Nonsense Codon (Nonsense Mutation)IBA 01/2007
1	AcidsIBA 01/2007
1	alpha-Glucosidases (Acid Maltase)IBA 01/2007

Therapy/Procedure

9	Enzyme Replacement Therapy 12/2020 - 11/2009
4	Therapeutics 01/2020 - 04/2009
2	Cell Transplantation 01/2021 - 01/2020
1	Immunotherapy 12/2019
1	Renal Dialysis (Hemodialysis) 09/2012